ABSTRACT
Introduction: One of the major challenges in hospitalized patients for Tuberculosis has been the association with the nosocomial SARS CoV2 infection. Both, viral infection and tuberculosis are affecting directly the immune response of the host with paraclinical expression - nonspecific inflammatory syndrome. Objective : Dynamic monitoring of the inflammatory syndrome in hospitalized patients with active TB that could suggest a superinfection with SARS CoV2 that requires the repeating of specific test. Method(s): We performed a comparative observational study on 45 patients, 25 diagnosed with TB and 25 with TB and co-infection with SARS CoV2, hospitalized in the Clinical Hospital of Pneumophthysiology Constanta for a 3 months period. At admission, all patients had a negative RT PCR COVID 19 test. The evolution of inflammatory tests was compared. Result(s): In the group with tuberculosis, the average values of ESR, CRP, Fibrinogen were 59.99 mm/h, 96 mcg/l, respectively 578 mg/dl. In the TB-COVID 19 group, blood tests were performed on average at 72-96 hours. We found a rapid increase in inflammatory syndrome between the first 2 sets of blood tests from the diagnosis of COVID 19 (ESR max 105mm/h, Fibrinogen-max 620mg/dl, CRP-max192mcg/l). Approximately 10 days after the diagnosis of COVID 19, after combined antiTB and antiviral treatment, there was a regression of the inflammatory syndrome to the values before co-infection(ESR=61mm/h, Fibrinogen=535mg/dl, CRP=84mcg/l). Conclusion(s): The increase in inflammatory markers during anti-tuberculosis treatment could be an alarm signal for the onset of COVID19 nosocomial infection in the event of a pandemic with OMICRON.